UNCG Campus Weekly

Campus Weekly is published each Wednesday when classes are in session. In the summer, it is published biweekly.

Dr. Nadja Cech

Photo of Dr. Nadja Cech. Dr. Nadja Cech (Chemistry and Biochemistry) received continued funding from the National Institutes of Health  (NIH) for the project “Strategies to Investigate Synergy in Botanical Medicines.” The project will apply an innovative two-pronged approach to the study of  synergy in goldenseal (Hydrastis canadensis.) Goldenseal is among the top 20 best selling herbal supplements in the United States, and shows promise of effectiveness against multidrug resistant Staphyolcoccus aureus (MRSA), which now kills more U.S. citizens each year than does AIDS.

The project aims to provide a comprehensive list of the array of compounds that are responsible for the antimicrobial activity of goldenseal, including details about their mechanism of action.  The long term goal is to support clinical trials of goldenseal and to enable effective quality control of commercially available goldenseal preparations.  The study will also demonstrate new methods by which the multiple constituents responsible for the activity of botanical dietary supplements can be identified.  These methods are expected to prove useful to other investigators who must account for the synergistic interactions that play a role in the activity of many complementary and alternative medicines.